Ethel Webi’s journey from an aspiring air hostess to a groundbreaking scientist in the field of genomics is a testament to the power of passion and perseverance. Growing up, Webi was captivated by the marvel of flight and the idea of becoming an air hostess. However, as she watched her mother, a teacher, at work, her dreams shifted towards science, particularly biotechnology. This shift in interest led her to pursue a degree in biotechnology at Jomo Kenyatta University of Agriculture and Technology (JKUAT), followed by a Master’s in Molecular Biology and Bioinformatics. Today, Webi is a PhD candidate at the University of Nairobi, focusing on genomic research that aims to combat East Coast Fever, a deadly cattle disease that has significant economic and social consequences in Kenya and Sub-Saharan Africa.
East Coast Fever is caused by a parasite transmitted by ticks during blood meals, and it has devastating effects on farmers and their families. Webi’s research is centered around developing a vaccine for this disease using CRISPR-Cas9, a revolutionary gene-editing technology. Her work involves manipulating the genetic makeup of the parasite, Theileria parva, to render it harmless while still stimulating an immune response in cattle. By knocking out harmful genes, Webi aims to create a live-attenuated vaccine that will protect livestock without the need for antibiotics, which can contribute to antimicrobial resistance (AMR). This innovative approach could provide a more durable and robust immune response, improving cattle health and, consequently, the livelihoods of farmers.
The process of developing this vaccine is complex and involves several phases. The first phase focused on establishing a method for genetic manipulation of the parasite, a task that had not been previously accomplished. The second phase involved identifying and knocking out genes that are not essential for the parasite’s survival. Despite facing challenges in culturing the parasite in the laboratory, Webi and her team have made significant progress in understanding the genetic functions of the parasite. Although they have not yet successfully knocked out all the harmful genes, their work has laid the foundation for future breakthroughs.
What sets Webi’s research apart is its potential to revolutionize livestock health without relying on antibiotics. The vaccine she is developing could offer a safer and more sustainable solution to East Coast Fever, addressing both the immediate health of livestock and the long-term environmental impact of antibiotic use. This innovative approach could also provide a model for combating other diseases affecting livestock in the region.
Webi’s journey has not been without its challenges. The complex nature of her research and the difficulties in culturing the parasite have tested her resolve. However, she has been fortunate to have a strong support system, including her mother, who has been her biggest motivator, and her academic mentors, who have provided both intellectual and emotional support throughout her PhD journey. Her supervisors, including professors and researchers from various institutions, have been instrumental in guiding her research and ensuring its success.
Beyond her scientific contributions, Webi is also part of a larger initiative aimed at improving livestock health in Kenya and East Africa. The Feed the Future Innovation Lab for Animal Health (AHIL) program, which is supported by USAID, works with local communities to improve cattle health and production. Webi’s work is part of a broader effort to enhance food security, economic welfare, and resilience in the region by addressing the health challenges that affect livestock.
Although Webi’s childhood dream of becoming an air hostess remains close to her heart, her passion for science and her commitment to improving livestock health have defined her path. As her PhD nears completion, she is excited about the potential impact of her research, which could transform the field of animal health and contribute to the well-being of communities reliant on livestock for their livelihoods. Through her groundbreaking work, Webi is not only advancing scientific knowledge but also making a tangible difference in the lives of farmers and their families.
